1st-in-Class Agents:
6.2.5
- Proline-rich antimicrobial peptides (AMPs)
- Protein translation inhibitors via a novel mechanism of action
- Two series (apidaecins and oncocins) in development
6.2.5
- Activity through binding to 70S ribosome & other related mechanisms
- No membrane disruption, unlike most other classes of AMPs
- No mammalian cytotoxicity or hemolysis (caused past AMP failures)
- Efficacious in variety of mouse infection models
6.2.5
- Activity vs. Gram-negative MDR, efflux-defective, and colistin-resistant strains
- No cross-resistance with strains resistant to ribosome-targeting antibiotics
- Efficacious in sepsis, thigh infection, and urinary tract infection in vivo models
- First known inhibitors of translation termination
6.2.5
