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Bacterial Persisters Lead to Chronic, Recurrent Infections

Persisters Diminish Clinical Efficacy

Antibiotic-Potentiator Combinations Eradicate Persisters

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Eliminating Persisters is Critical to Limiting Recurrence & Resistance:

  • Persisters are evolutionary reservoir where resistant organisms emerge
  • Strategy works with aminoglycosides, fluoroquinlones, beta-lactams
  • Potential for life-cycle management in multiple antibiotic classes

Overall Anti-Persister Strategy:

  • Deliver Combination

  • Re-Sensitize Bacteria

  • Eradicate Persisters

  • Limit Recurrence/Resistance